anti-CD25 Allophycocyanin

Expression of human CD25 (the alpha subunit of the IL-2 receptor complex) is dramatically upregulated on activated T cells, B cells, NK cells and macrophages (3).  Antibodies to CD25 are being studied for potential use as an immunodirected therapy to selectively attack (kill) CD25 expressing cells (4).

Isotype: Murine IgG2a

Immunogen: Stimulated PBMC

Specificity: Antibody  7G7B6 recognizes epitope B of the IL-2 alpha receptor of about 55 kd (1,6).

Functional  Application: Antibody 7G7B6 does not block IL-2 binding to its receptor (1).

References:

1.   L.A. Rubin, et al, (1985)  Hybridoma  4:91-102.

2.   B. Boutin, et al, (1989) Neuropediatrics  20: 202-206.

3.   T.A. Waldmann, et al, (1989) Annu Rev Biochem  58: 875-911.

4.   T.A. Waldmann, et al, (1995) Blood  86: 4063-4075.

5.   U.S. Patent No. 4,707,443.

6.   Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 403-406.

7)  MP Grange, MC Dokhelar, et al. (2000) J Virol 74(24): 11734-11743.

8)  V Blot, MP Grange, et al. (2006) Retrovirology 3: 62  doi: 10.1186/1742-4690-3-62.

USD $325.00
In cart: 0
= $325.00
Catalog #:
174-060
Form:
APC
Size:
120 tests
Alternate Name:
IL-2R α, TAC, p55
Clone:
7G7B6
Applications:
8), FC, FX(7, IHC(2)

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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