Human CD23 is a low affinity receptor for IgE (Fc epsilon RII) found primarily on mature B cells and also on eosinophils, monocytes, dendritic cells, platelets, and a subset of thymic epithelial cells. CD23 interacts with CD21 (4).
Isotype: Murine IgG1
Immunogen: Human peripheral myeloma cells
Specificity: Antibody BU38 recognizes the CD23 molecule of 45 kd (1, 3).
Functional Application: Antibody BU38 functions as a CD23 agonist when crosslinked with anti-Mouse polyclonal antibody (5,6). Biotinylated BU38 has been used for magnetic depletion of Eosinophils (7).
1. Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 67-81.
2. D.L. Hardie, et al, (1993) Eur J Immunol 23: 997-1004.
3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 530-538.
4. J.Y. Bonnefoy, et al, (1995) Curr Opin Immunol 7: 355-359.