anti-CD23 FITC Conjugate

Human CD23 is a low affinity receptor for IgE (Fc epsilon RII) found primarily on mature B cells and also on eosinophils, monocytes, dendritic cells, platelets, and a subset of thymic epithelial cells.  CD23 interacts with CD21 (4).

Isotype: Murine IgG1

Immunogen: Human peripheral myeloma cells

Specificity: Antibody BU38 recognizes the CD23 molecule of 45 kd (1, 3). 

Functional Application:  Antibody BU38 functions as a CD23 agonist when crosslinked with anti-Mouse polyclonal antibody (5,6). Biotinylated BU38 has been used for magnetic depletion of Eosinophils (7).

References:

1.  Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford, (1989) p. 67-81.

2.  D.L. Hardie, et al, (1993)  Eur J Immunol  23: 997-1004.

3.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 530-538.

4.  J.Y. Bonnefoy, et al, (1995) Curr Opin Immunol  7: 355-359.

5.  M.A. Chan, L.J. Rosenwasser, et al (20103)  Clin Immunol 137(3): 330-336.

6.  M.A. Chan, L.J. Rosenwasser, et al (2013)  Am J Respir Cell Mol Biol doi:10.1165/rcmb.2013-0112OC

7. N Singh, MF Denny, et al. (2016) Dis Model Mech 9(8): 885-97.  PMID: 27483354.

USD $235.00
In cart: 0
= $235.00
Catalog #:
172-040
Form:
FITC
Size:
120 tests
Alternate Name:
Fcε RII, IgE Receptor
Clone:
BU38
Applications:
FC, FPS, WB

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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