anti-CD18 Purified (Preservative-free)

Human CD18 (beta integrin) forms a heterodimer with either alpha L, alpha M, or alpha X integrins (CD11a, b or c).  CD11/CD18 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses.

Isotype: Murine IgG2a

Immunogen: Human peripheral blood monocytes

Specificity: Antibody IB4 recognizes the beta 2 integrin subunit (CD18) adhesion molecule of about 95 kd (1, 6).

Functional Application: Antibody IB4 blocks binding of ICAM-1 and ICAM-3 to LFA-1 (2, 5).

References:

1.  S.D. Wright, et al, (1983) Proc Natl Acad Sci USA  80: 5699-5703.

2.  R.C. Landis, et al, (1994) J Cell Biol  126: 529-537.

3.  M. Kaneko, et al, (1995) J Immunol  155: 2631-2641.

4.  A. Mazzone & G. Ricevuti, (1995) Haematologica  80: 161-175.

5.  M.E. Berman, et al, (1996) J Immunol 156: 1515-1524.

6.  K Welzenbach, G Weitz-Scmidt, et al (2002) J Biol Chem 277(12): 10590 – 10598. PMID: 11781316

USD $175.00
In cart: 0
= $175.00
Catalog #:
167-820
Form:
Pur/PF
Size:
100 µg
Alternate Name:
integrinβ 2
Clone:
IB4
Applications:
FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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