anti-CD11c R-PE Conjugate

Human CD11c (alpha X integrin) complexes with CD18 (beta 2 integrin) to form the complement receptor type 4 (CR4) heterodimer which binds to fibrinogen and is involved with monocyte/granulocyte adhesion during inflammatory responses (2).  CD11c expression is restricted to leukocytes mainly of myeloid lineage with highest expression on macrophages.

Isotype: Murine IgG1

Immunogen: Human rheumatoid synovial fluid cells/monocytes

Specificity: Antibody 3.9 recognizes the human integrin alpha X subunit (CD11c) of about 150 kd (1, 4).  It is cross reactive with cynomolgus monkey CD11c (5).

References:

1.  N. Hogg, et al, (1986) Eur J Immunol  16: 240-248.

2.  S.A. Stacker & T.A. Springer, (1991) J Immunol  146: 648-655.

3.  M. Patarroyo, (1994) Immunobiology  191: 474-477.

4.  Leukocyte Typing V (1995) (S.F. Schlossman, et al., eds.) Oxford University Press, Oxford,p. 1590-1592.

5. Yoshino N, Honda M, et al. (2000) Exp Anim 49(2):97-110.

USD $275.00
In cart: 0
= $275.00
Catalog #:
160-050
Form:
R-PE
Size:
120 tests
Alternate Name:
Integrinα X, CR4, p150
Clone:
3.9
Applications:
FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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