anti-CD11a FITC Conjugate

Human CD11a (alpha L integrin) complexes with CD18 (beta 2 integrin) to form the LFA-1 heterodimer adhesion molecule which binds to three ICAM’s 1, 2, and 3, also designated  CD54, CD102, and CD50 respectively.  LFA-1 is expressed on lymphocytes, monocytes and neutrophils and plays a role in cell-cell adhesion (6).

Isotype: Murine IgG2a

Immunogen: Human monocytes

Specificity: Antibody 38 recognizes the I domain of the human integrin alpha L subunit (CD11a) of about 180 kd (1, 3, 7).

Functional Application: Antibody 38 blocks binding of ICAM-1 and ICAM-3 to LFA-1 at 5-10 ug/ml (7, 9).

References:

1.  I. Dransfield & N. Hogg, (1989) EMBO J 12: 3759-3765.

2.  I. Dransfield, et al, (1992) J Cell Biol  116: 1527-1535.

3.  R.C. Landis, et al, (1994) J Cell Biol  126: 529-537.

4.  A.M. Randi & N. Hogg, (1994) JBC  269:12395-12398.

5.  P. Stanley, et al, (1994) EMBO J  13:1790-1798

6.  Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 1581-1592.   

7.  C.L. Holness, et al, (1995) J Biol Chem  270: 877-884.

8.   M. Galdiero, et al. Microbiology 147 (2001), 2697-2704

9. T Mizuno, K Mori, et al (1996) J Biol Chem 272(2): 1156-63. PMID: 8995416

USD $235.00
In cart: 0
= $235.00
Catalog #:
158-040
Form:
FITC
Size:
120 tests
Alternate Name:
LFA-1, integrinα L
Clone:
38
Applications:
FC, WB

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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