anti-CD8 (clone 14) Purified (Preservative-free)
Human CD8 is a heterodimeric protein consisting of an alpha and beta chain, each about 33 kd. CD8 is expressed on most thymocytes and on about one third of peripheral blood T cells. CD8 is a co-receptor involved in antigen recognition and binds to the alpha 2 and alpha 3 domain of MHC Class I molecules (3, 4).
Antibodies 14 and UCHT4 (cat #153-020) each bind to a distinct epitope of CD8 and are suitable as a matched pair for EIA using UCHT4 as capture and Biotinylated clone 14(cat# 154-030) as detector.
Isotype: Murine IgG1 kappa
Immunogen: Human thymocytes
Specificity: Antibody 14 recognizes the CD8 alpha chain of approximately 33 kd (1).
References:
1. Leukocyte Typing II (E.L. Reinherz, et al, eds.) Springer Verlag, New York, (1986)
2. R. Zamoyska, (1994) Immunity 1: 243-246.
3. Leukocyte Typing V ( S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 353-356.
4. J. Sun, et al, (1995) J Exp Med 182: 1275-1280.