anti-CD8 (clone UCHT4) Purified (Preservative-free)
Human CD8 is a heterodimeric protein consisting of an alpha and beta chain, each about 33 kd. CD8 is expressed on most thymocytes and on about one third of peripheral blood T cells. CD8 is a co-receptor involved in antigen recognition and binds to the alpha 2 and alpha 3 domain of MHC Class I molecules (3, 4).
Antibodies UCHT4 and 14 (cat #154-020) each bind to a distinct epitope of CD8 and are suitable as a matched pair for EIA using UCHT4 as capture and Biotinylated clone 14(cat# 154-030) as detector.
Isotype: Murine IgG2a
Immunogen: Human thymocytes/Sezary T cells
Specificity: Antibody UCHT4 recognizes the CD8 alpha chain of approximately 33 kd (1).
References:
1. (UCHT4 clone) A. Fischer, et al, (1983) Immunology 48: 177-186.
2. (Review CD8) R. Zamoyska, (1994) Immunity 1: 243-246.
3. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 353-356.
4. J. Sun, et al, (1995) J Exp Med 182: 1275-1280.