anti-CD8 (clone UCHT4) R-PE Conjugate

Human CD8 is a heterodimeric protein consisting of an alpha and beta chain, each about 33 kd.  CD8 is expressed on most thymocytes and on about one third of peripheral blood T cells.  CD8 is a co-receptor involved in antigen recognition and binds to the alpha 2 and alpha 3 domain of MHC Class I molecules (3, 4).

Antibodies UCHT4 and  14 (cat #154-020) each bind to a distinct epitope of CD8 and are suitable as a matched pair for EIA using UCHT4 as capture and Biotinylated clone 14(cat# 154-030) as detector.

Isotype: Murine IgG2a

Immunogen: Human thymocytes/Sezary T cells

Specificity: Antibody UCHT4 recognizes the CD8 alpha chain of approximately 33 kd (1).

References:

1. (UCHT4 clone) A. Fischer, et al,  (1983) Immunology 48: 177-186.

2.  (Review CD8) R. Zamoyska, (1994) Immunity  1: 243-246.

3.  Leukocyte Typing V (S.F. Schlossman, et al, eds.)  Oxford University Press, Oxford, (1995)  p. 353-356.

4.  J. Sun, et al, (1995) J Exp Med  182: 1275-1280.

5.  J Hirst, MS Robinson, et al.(2007) Traffic 8:594-604.

USD $300.00
In cart: 0
= $300.00
Catalog #:
153-050
Form:
R-PE
Size:
120 tests
Alternate Name:
T8, Leu2, CD8α
Clone:
UCHT4
Applications:
EIA(capture), FC, ICC(5), WB

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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