Human CD7 is one of the earliest T lineage markers and is found on most thymocytes and peripheral blood T cells. The function of CD7 is not yet fully known, although cross-linking of CD7 with antibodies induces a T cell transmembrane calcium flux (2) and CD7 expression is induced by ionomycin (1).
Isotype: Murine IgG2b
Immunogen: Human HSB2-T cells
Specificity: Antibody 3Ale recognizes a CD7 molecule of 40 kd (1, 2).
Functional Application: Antibody 3Ale induces T cell transmembrane calcium flux.
1. R.E. Ware, et al, (1989) J Immunol 143: 3632-3640.
2. R.E. Ware, et al, (1991) J Immunol 147: 2787-2794.