anti-CD5 FITC Conjugate

Human CD5 is believed to be an alternative signaling molecule found on all mature T cells, on most thymocytes and on a subpopulation of mature B cells expressing autoantibodies (4).  The ligand for CD5 is CD72. 

Isotype:  Murine IgG1

Immunogen: Human thymocytes/Sezary T cells

Specificity: Antibody UCHT2 recognizes epitope 2 of the CD5 molecule of approximately 67 kd (1, 2).

Functional Application: Antibody UCHT2 does not stimulate CD5+ PBMNC (2).

References:

1.  P.C.L. Beverly & R.E. Callard. “Protides of the Biological Fluids” (1981) Vol. 29: 653-658, H. Peeters (ed.),    Pergamon Press, Oxford.

2.  Leukocyte Typing IV (W. Knapp, et al, eds.) Oxford University Press, Oxford (1989) p. 331-338.

3.  G.S. Wood & P.S. Freudenthal, (1992) Am J Pathol 141: 789-795.

4.  P.M. Lydyard, et al, (1993) Immunol Lett  38: 159-166.