anti-CD4 (D2) Purified (Preservative-free)
Human CD4 is a cell surface glycoprotein of 55 kd expressed on most thymocytes, on about two thirds of peripheral T cells, and on some monocyte macrophage lineage cells. CD4 interacts with MHC Class II molecules in an accessory role during foreign antigen recognition by T cells. The extracellular portion of CD4 is an array of four Ig-like domains. The amino terminal region of CD4 is a receptor for the HIV-1 viral protein gp120.
Antibodies QS4120 (cat #147-020) and M-T441 each bind to a distinct epitope of CD4 and are suitable as a matched pair for EIA using QS4120 as capture and Biotinylated M-T441(cat# 148-030) as detector.
Isotype: Murine IgG2b
Immunogen: P815 cells transfected with human CD4
Specificity: Antibody M-T441 recognizes an extracellular epitope within the domain 2 region of the CD4 molecule and reacts with human CD4 cell transfectants (1). It has been reported to cross react with Baboon CD4.
1. Characterized by the laboratory of Dr. E.P. Reiber.
2. Leukocyte Typing V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford, (1995) p. 476-478.
3. R. König, et al, (1995) J Exp Med 182: 779-787.