anti-human IgM R-PE Conjugate

Human surface membrane bound IgM complexes with a heterodimer of transmembrane proteins of Ig alpha and Ig beta (CD79a and CD79b) to form the B cell antigen receptor (BCR).  The BCR complex plays an important role in B cell development and activation (3).  The transmembrane region of mIgM is essential for functional BCR complex assembly (4).

Isotype: Murine IgG1

Immunogen: Prolymphocytic leukemic B cells

Specificity: Antibody UCHB1 recognizes surface expressed IgM (1, 2).

Functional Application: Antibody UCHB1 can deliver a costimulatory signal to B cells In Vitro(1).

References:

1.  R.J. Armitage, et al, (1988) Eur J Immunol  18(1): 67-76.

2.  J. Smith-Ravin, et al, (1990) Clin Exp Immunol  82: 181-187.

3.  A.L. DeFranco, et al, (1994) Chem Immunol  59: 156-172.

4.  S.A. Grupp, et al, (1995) J Exp Med  181: 161-168.

USD $275.00
In cart: 0
= $275.00
Catalog #:
141-050
Form:
R-PE
Size:
120 tests
Alternate Name:
anti-IgM, IgM, anti human IgM
Clone:
UCHB1
Applications:
EIA, FC

Application Key

FC
Flow Cytometry
WB
Western blot
EIA
Enzyme Immunoassay
IHC
Immunohistochemistry
ICC
Immunocytochemistry
FPS
Fixed paraffin section
PS
Paraffin section
IP
Immunoprecipitation
FX
Fixed cells or tissues

Applications indicated have been either tested in-house or reported. Products may be functional for applications not indicated.

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