anti-human IgM R-PE Conjugate

Human surface membrane bound IgM complexes with a heterodimer of transmembrane proteins of Ig alpha and Ig beta (CD79a and CD79b) to form the B cell antigen receptor (BCR).  The BCR complex plays an important role in B cell development and activation (3).  The transmembrane region of mIgM is essential for functional BCR complex assembly (4).

Isotype: Murine IgG1

Immunogen: Prolymphocytic leukemic B cells

Specificity: Antibody UCHB1 recognizes surface expressed IgM (1, 2).

Functional Application: Antibody UCHB1 can deliver a costimulatory signal to B cells In Vitro(1).

References:

1.  R.J. Armitage, et al, (1988) Eur J Immunol  18(1): 67-76.

2.  J. Smith-Ravin, et al, (1990) Clin Exp Immunol  82: 181-187.

3.  A.L. DeFranco, et al, (1994) Chem Immunol  59: 156-172.

4.  S.A. Grupp, et al, (1995) J Exp Med  181: 161-168.

USD $275.00
In cart: 0
= $275.00
Catalog #:
141-050
Form:
R-PE
Size:
120 tests
Alternate Name:
anti-IgM, IgM, anti human IgM
Clone:
UCHB1
Categories:

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