An Ohio research group tested the efficacy of inactivated Swine Influenza virus (SwlV) encapsulated in 200–300 nm diameter PLGA (poly lactic co-glycolic acid) microspheres. Pigs were immunized twice intranasaly.  While control pigs had fever for four days, treated pigs showed no clinical flu symptoms.  “Biodegradable nanoparticle delivery of inactivated swine influenza virus vaccine provides heterologous […]

CD36 is a scavenger receptor which can bind to various ligands as well as long chain fatty acids.  It plays a role in innate immunity as well as metabolism.  The authors use transport inhibitors, and uptake of 14-C labeled Phosphate diester of alpha-Tocopheryl (Vitamin E ) to implicate the CD36/PI3Ky as an important pathway for

Visit Ancell at the 2016 Autumn Immunology Conference Nov 18 – 20 at the downtown Marriott in Chicago!

Ancell anti-human FOXP3 mAb and Biotin conjugate now available!  Other conjugates coming soon!   Clone ANCFX2D7 Purified mAb   333-020 Biotinylated    333-030 FITC              333-040 PE                333-050

“Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells” Xuehui He, Ruben L Smeets,  Esther van Rijssen, Annemieke MH Boots, Irma Joosten, Hans JPM Koenen.  (2016) Dissertation Submitted for Publication,  Radbound Univ Med Center and Groningen Univ Med Center, The Netherlands. Ancell anti-CD28 Superagonist  Clone ANC28.1/5D10

Adding Low density lipoprotein to FITC labeled Group A Steptococcus increased U-937 phagocytosis rate.   This effect was blocked when cells were pre incubated with Ancell anti-CD36 mAb clone SMO. “LDL acts as an opsonin enhancing the phagocytosis of group A Streptococcus by monocyte and whole human blood”  Lulei Zhou, Runlin Han, et al. (2016) Medical

Come and visit Ancell at the American Association of Immunologist’s meeting in Seattle May 13 – May 16th, booth #816.  Ask for an Ancell  T shirt.  They go fast!

Macrophages derived in culture from SLE patients are directed into secreting proinflammatory cytokines by anti-C1q auto antibodies bound to immobilized C1q complement protein. Pre blocking these monocytes with anti-CD32 (FcgRII ) F(ab’)2 reduced cytokine secretion levels significantly. “Anti-C1q Autoantibodies from Systemic Lupus Erythematosus Patients Induce a Proinflammatory Phenotype in Macrophages.”  Sophia Thanei, Marten Trendelenburg  J

Using TALEN(Transcription Activator-Like Effector Nucleases) technology, these researchers from Seattle Children’s Research succeeded in restoring copies of CD154( CD40L) gene with 3’ UTR under control of its endogenous promoter in human T cells from a patient with X-Linked Hyper-IgM Syndrome (X-HIGM). “Targeted gene editing restores regulated CD40L expression and function in X-HIGM T cells.” N

Neutrophil Extracellular Trap (NET) is a mechanism by which bacteria and other pathogenic organisms are rendered trapped in a site of inflammation.  An activated Neutrophil extrudes it own genomic DNA, rich with histones and other proteins, to trap invading pathogenic organisms.  However, in SLE patients, a distinct subset of Neutrophils, Low Density Granulocytes (LDGs) are