T cell receptor Beta Constant region used to distinguish malignant from normal T cells
The authors prove the concept that an anti-TCR Cb1 CAR cell based on the epitope of Jovi-1 anti-TCR Cb1 mAb can kill malignant T cell leukemic cells without destroying TCR Cb2 cells. ”Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies.” Paul M Maciocia, Martin A Pule, et al. (2017) […]
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