Engagement of CD134(OX40) by its Ligand (CD252) induces an intracellular signaling complex which  includes PKB, and PI3K, and requires TRAF2. Takanori S, H Choi, M Croft. (2011) J Immunol 186(6):3547-3555.   Ancell Products: Recombinant human CD134-muIg Fusion protein Recombinant human CD252(OX40)-muCD8 Monoclonal anti-human CD134(OX40) Monoclonal anti-human CD252(OX40L)  

In mice, use of CD28 superagonist has been shown to increase the % of Treg cells, and protect from Rheumatoid Arthritis mediated bone destruction.Marlo M Zaiss, Jean-Pierre David, et al. (2010) J Immunol 184: 7238-7246. Ancell anti-CD28 antibody clone ANC28.1/5D10 has been characterized as a superagonist. This mAb has been found to be capable of stimulating