BAFF levels in bronchoalveolar fluid are higher in allergic vs tolerant mice, and increase with repeated immunization. Blocking BAFF interactions may prove an effective therapeutic intervention for chronic respiratory diseases. “Investigating the Role of BAFF in Murine Models of Allergic Asthma” A Lorenz, A Meyer-Bahlburg, et al. (2014) European Respiratory Journal 44(Suppl 58): 4213.   […]

In a mouse adoptive adoptive transfer T cell exhaustion model improved T cell proliferation was observed when agonistic antibodies against CD27 and CD134 were included with the CD274 blockade.  “OX40- and CD27-Mediated Costimulation Synergizes with Anti-PD-L1 Blockade by Forcing Exhausted CD8+ T Cells to Exit Quiescence” Sarah L. Buchan, Aymen Al-Shamkhani, Ronjon Chakraverty, et al. 

oxLDL-IC pathology was mediated by CD36 and CD64 receptors on retinal pericytes.  “Immune complex formation in human diabetic retina enhances toxicity of oxidized LDL towards retinal capillary pericytes.” D Fu, T J Lyons, et al. (May, 2014) J Lipid Res 55: 860-869.  PMID: 24616481 Ancell reagents were used in this study to selectively block IC

A matched pair of EIA antibodies to detect CD272(BTLA)  

Autumn Immunolgy Conference in Chicago is November 21st through 24th.  Visit our booth!

Level of CD4+CD39+/CD161+ T cell sub population in muscosal membranes and peripheral blood correlate to severity of Crohns Disease.  “CD39 and CD161 Modulate Th17 Responses in Crohn’s Disease” A Bai, S C Robson, et al. (2014) J Immunol 193(7): 3366-3377. PMID:25172498 Relevant Ancell antibodies and conjugates anti-human CD4 anti-human CD39 anti-human CD161

Human CD326 (EpCAM, EGP2, HEA) is a 40kD glycoprotein expressed on epithelial cells and many carcinomas.  It is an adhesion molecule whose function is implicated in carcinogenesis and erythropoesis. CD326 has great potential as a therapeutic and diagnostic marker for cancer (2, 3). 1) Rao CG, et al. (2005) Int. J. Oncol  27: 49 2)

Using transgenic mouse models and BM transplantation, it was observed that numbers of expanded thymic Treg are proportionate to number of thymic B cells present during autoimmune development. “A Role for Intrathymic B Cells in the Generation of Natural Regulatory T Cells.” Stacey N Walters, Shane Grey, et al. (2014) J Immunol 193(1): 170-176. PMID:24872190

CD273 binds to a distinct site on RGMb (Repulsive Guidance Molecule Family member B) from Bone Morphogenic proteins (BMP).  In mice, blockade of this interaction impaired development of respiratory tolerance. “RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance”  Y Xiao, G J Freeman, et al. (2014) JEM

  anti-GARP/FITC  catalog #277-040 anti-GARP/PE  catalog #277-050 anti-GARP/Biotin  catalog #277-030 anti-GARP mAb catalog #277-020   Other Ancell human Treg Products   CD4 CD39 CD357(AITR/GITR) CD45RA CD45RO CD127 CD25