This group demonstrated that physiologic levels of HDL act as an effective opsonin, facilitating uptake of M41-type Group A Streptococcus by human monocyte cell line U-937.  Pre incubation with anti-CD36 antibody (clone SM0) completely blocked this phagocytosis. “High-density lipoprotein acts as an opsonin to enhance phagocytosis of group A streptococcus by U937 cells.” Ling Liu, […]

“CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28−CD8+ T Cells”   J Leitner, P Steinberger, et al. (2015) J Immunol 195(2): 477-87. PMID: 26041540.   Related Ancell Research Products anti-CD2 mAb         (clone 1E7E8 UMCD2) anti-CD58(LFA-3)   (clone TS2/9)

“Polyfunctional, Pathogenic CD161+ Th17 Lineage Cells Are Resistant to Regulatory T Cell–Mediated Suppression in the Context of Autoimmunity”  S A Basdeo, J M Fletcher, et al. (2015) J Immunol 195(2): 528-540.  PMID 26062995.   Ancell anti-Human CD161 antibody Products

Matched pair of anti-human CD155(PVR) mAbs for Flow Cytometry and EIA Clone ANC2B2    Purified                                 255-020 Biotinylated                        255-030   Clone ANC6A3  Purified                                 350-020 Biotinylated                        350-030   Recombinant Soluble Poliovirus Receptor CD155-muIg Binds to Ligand(s) Upregulated on Stimulated Human Peripheral Blood Lymphoid Cells Recombinant Human CD155(PVR)-muIg Purified CD155-muIg            555-020 Biotinylated

  “Analysis of Programmed Death-1 in Patients with Psoriatic Arthritis” M Peled, A Mor, et al. Feb 10 2015 Inflammation PMID: 25663558     Related Ancell Research Products     Human CD279 (PD-1) Products (mAbs and Recombinant Proteins)   Superagonist anti-human CD28 mAb   anti-human CD3 mAb

  “Nitric Ooxide Donors Iincrease PVR/CD155 DNAM-1 Ligand Expression in Multiple Myeloma Cell: Role of DNA Damage Response Activation”  Cinzia Fionda, Marco Cippitelli, et al. (2015) BMC Cancer 15(1): 17 PMID: 25609078    Ancell human CD155 recombinant protein and monoclonal antibody products available soon!

“Semaforin Sema4D in the Immune System in Mulple Sclerosis.” E.M. Kulkina, I.V. Nekrasova, et al. (June 2014) Bull Exp Biol Med 157(2): 234-237. PMID 24952493 “Expression of Semaphorin CD100 on Peripheral Blood T-Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis”  T.N. Trushnikova, I.V. Nekrasova, et al. (Oct 2013) Multiple Sclerosis 113(10 pt 2): 47-51. PMID 24300815

The Macrophage Mediator, Maresin-1, is derived from the Omega-3 Fatty acid DHA. In a murine asthma model exogenously added Maresin-1 augmented T regulatory cells expansion and reduced lung inflammation with lower detectable levels of IL-5 and IL-13   “Maresin-1 Engages Regulatory T Cells To Limit Type 2 Innate Lymphoid Cell Activation and Promote Resolution of

BAFF levels in bronchoalveolar fluid are higher in allergic vs tolerant mice, and increase with repeated immunization. Blocking BAFF interactions may prove an effective therapeutic intervention for chronic respiratory diseases. “Investigating the Role of BAFF in Murine Models of Allergic Asthma” A Lorenz, A Meyer-Bahlburg, et al. (2014) European Respiratory Journal 44(Suppl 58): 4213.  

In a mouse adoptive adoptive transfer T cell exhaustion model improved T cell proliferation was observed when agonistic antibodies against CD27 and CD134 were included with the CD274 blockade.  “OX40- and CD27-Mediated Costimulation Synergizes with Anti-PD-L1 Blockade by Forcing Exhausted CD8+ T Cells to Exit Quiescence” Sarah L. Buchan, Aymen Al-Shamkhani, Ronjon Chakraverty, et al.