GITR signaling induces proliferation of both Teff and Treg cells in mice

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Despite the pronounced proliferative effect of recombinant pentameric GITRL on T cells, MC38 adenocarcinoma tumor failed to regress due to suppressive effect of accumulating Treg  in tumor tissue and draining lymph node.

“Authentic GITR Signaling Fails to Induce Tumor Regression unless Foxp3+ Regulatory T Ccells Are Depleted” Y.H. Kim, B.S. Kwon, et al. (2015) J Immunol  195(10): 4721-4729.  PMID: 26423152

 

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