Conformation Dependent Oncofetal Epitope of CD98 Identified

This Korean research group screened mAbs generated against Multiple Myeloma and developed a mAb (clone NPB15) specific to an epitope of CD98 present on stem and cancer cells, but not on CD98 presented by more differentiated tissues. They demonstrated the therapeutic potential of this mAb.

“A monoclonal antibody recognizing CD98 on human embryonic stem cells shows anti-tumor activity in hepatocellular carcinoma xenografts” Keunpyo Lim, Chun Jeih Ryu, et al. Cancer Immunology, Immunotherapy (2024 Sept 11) 73(11): 231. doi: 10.1007/s00262-0

Ancell anti-CD98 mAb(clone UM7F8)