Combining CD27 and CD134(OX40) stimulation with PD-L1 Blockade is beneficial to recovering exhausted T cell function

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In a mouse adoptive adoptive transfer T cell exhaustion model improved T cell proliferation was observed when agonistic antibodies against CD27 and CD134 were included with the CD274 blockade. 

“OX40- and CD27-Mediated Costimulation Synergizes with Anti-PD-L1 Blockade by Forcing Exhausted CD8+ T Cells to Exit Quiescence” Sarah L. Buchan, Aymen Al-Shamkhani, Ronjon Chakraverty, et al.  (2015) J Immunol 194: 125–133.

PMID: 25404365

Related Ancell Products

anti-human CD27 mAb

anti-human CD134(OX40) mAb

anti-human CD279(PD-1) mAb

anti-human CD274(PD-L1) mAb

Recombinant human CD134(OX40)-muIg

Recombinant human CD279(PD-1)-muIg

Recombinant human CD274(PD-L1)-muIg