CD43 is the major ligand for recruitment of Th17 cells by CD62E on vascular endothelium in mice

This is distinct from recruitment of Th1 cells where CD162 is also necessary for rolling.  CD43 mediated adhesion could provide a means to selectively manipulate Th17 immune response.

“CD43 Functions as an E-Selectin Ligand for Th17 Cells in Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo”  Francisco Velazquez, Pilar Alcaide, et al. (Feb 2016) Journal of Immunology 196(3): 1305-1316.  PMID: 26700769

Relevant Ancell anti-Human mAb products

anti-CD62E (E-Selectin) 

anti-CD162 (PSGL1)

anti-CD43

anti-CD44