CD36 is a scavenger receptor which can bind to various ligands as well as long chain fatty acids. It plays a role in innate immunity as well as metabolism. The authors use transport inhibitors, and uptake of 14-C labeled Phosphate diester of alpha-Tocopheryl (Vitamin E ) to implicate the CD36/PI3Ky as an important pathway for monocyte activation and subsequent secretion of Vascular Endothelial Growth Factor(VEGF).
“alpha-Tocopheryl Phosphate Induces VEGF Expression via CD36/PI3Ky in THP-1 Monocytes” J M Zingg, A Azzi, M Meydani, J Cell Biochem DOI: 10.1002/jcb.25871 PMID: 28059487