CD147(Basigin) Facilitates Apolipoprotein D Cellular Internalization

Internalized ApoD is colocalized in intracellular vesicular compartments with CD147.  Downregulation of CD147 results in lower ApoD internalization.  Induction of CD147 overexpression resulted in increased ApoD internalization.  CD147 is a putative receptor for ApoD.

“Apolipoprotein D Internalization Is a Basigin-dependent Mechanism” Ouafa Najyb, Louise Brissette, Eric Rassart (June 2015) J Biol Chem 290: 16077-16087. PMID: 25918162

 

Ancell anti-CD147 mAb (Clone UM-8D6)