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PD-1 (CD279) levels correlate with disease score for tender and swollen joints in Psoriatic Arthritis patients.

  “Analysis of Programmed Death-1 in Patients with Psoriatic Arthritis” M Peled, A Mor, et al. Feb 10 2015 Inflammation PMID: 25663558     Related Ancell Research Products     Human CD279 (PD-1) Products (mAbs and Recombinant Proteins)   Superagonist anti-human CD28 mAb   anti-human CD3 mAb

PD-1 (CD279) levels correlate with disease score for tender and swollen joints in Psoriatic Arthritis patients. Read More »

CD155(PVR, Necl-5) tumor expression is unregulated by Nitric Oxide. This has implications for NK cell biology.

  “Nitric Ooxide Donors Iincrease PVR/CD155 DNAM-1 Ligand Expression in Multiple Myeloma Cell: Role of DNA Damage Response Activation”  Cinzia Fionda, Marco Cippitelli, et al. (2015) BMC Cancer 15(1): 17 PMID: 25609078    Ancell human CD155 recombinant protein and monoclonal antibody products available soon!

CD155(PVR, Necl-5) tumor expression is unregulated by Nitric Oxide. This has implications for NK cell biology. Read More »

CD100 (Sema4D) is a Useful Marker for Multiple Sclerosis

“Semaforin Sema4D in the Immune System in Mulple Sclerosis.” E.M. Kulkina, I.V. Nekrasova, et al. (June 2014) Bull Exp Biol Med 157(2): 234-237. PMID 24952493 “Expression of Semaphorin CD100 on Peripheral Blood T-Lymphocytes in Patients with Relapsing-Remitting Multiple Sclerosis”  T.N. Trushnikova, I.V. Nekrasova, et al. (Oct 2013) Multiple Sclerosis 113(10 pt 2): 47-51. PMID 24300815

CD100 (Sema4D) is a Useful Marker for Multiple Sclerosis Read More »

BAFF(CD257) levels correlate with severity of Asthma

BAFF levels in bronchoalveolar fluid are higher in allergic vs tolerant mice, and increase with repeated immunization. Blocking BAFF interactions may prove an effective therapeutic intervention for chronic respiratory diseases. “Investigating the Role of BAFF in Murine Models of Allergic Asthma” A Lorenz, A Meyer-Bahlburg, et al. (2014) European Respiratory Journal 44(Suppl 58): 4213.  

BAFF(CD257) levels correlate with severity of Asthma Read More »

Combining CD27 and CD134(OX40) stimulation with PD-L1 Blockade is beneficial to recovering exhausted T cell function

In a mouse adoptive adoptive transfer T cell exhaustion model improved T cell proliferation was observed when agonistic antibodies against CD27 and CD134 were included with the CD274 blockade.  “OX40- and CD27-Mediated Costimulation Synergizes with Anti-PD-L1 Blockade by Forcing Exhausted CD8+ T Cells to Exit Quiescence” Sarah L. Buchan, Aymen Al-Shamkhani, Ronjon Chakraverty, et al. 

Combining CD27 and CD134(OX40) stimulation with PD-L1 Blockade is beneficial to recovering exhausted T cell function Read More »

Oxidized Low Density Lipoprotein-Immune complexes linked to the Severity of Retinopathy in Type II Diabetes Patients

oxLDL-IC pathology was mediated by CD36 and CD64 receptors on retinal pericytes.  “Immune complex formation in human diabetic retina enhances toxicity of oxidized LDL towards retinal capillary pericytes.” D Fu, T J Lyons, et al. (May, 2014) J Lipid Res 55: 860-869.  PMID: 24616481 Ancell reagents were used in this study to selectively block IC

Oxidized Low Density Lipoprotein-Immune complexes linked to the Severity of Retinopathy in Type II Diabetes Patients Read More »

CD39 and CD161 are useful markers for observing Th17 inflammatory T cell response.

Level of CD4+CD39+/CD161+ T cell sub population in muscosal membranes and peripheral blood correlate to severity of Crohns Disease.  “CD39 and CD161 Modulate Th17 Responses in Crohn’s Disease” A Bai, S C Robson, et al. (2014) J Immunol 193(7): 3366-3377. PMID:25172498 Relevant Ancell antibodies and conjugates anti-human CD4 anti-human CD39 anti-human CD161

CD39 and CD161 are useful markers for observing Th17 inflammatory T cell response. Read More »