This is distinct from recruitment of Th1 cells where CD162 is also necessary for rolling. CD43 mediated adhesion could provide a means to selectively manipulate Th17 immune response. “CD43 Functions as an E-Selectin Ligand for Th17 Cells in Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In […]
These effects are Treg and IL-4 independent, and are instead dependant on the helminth specific Th2-mediated Eosinophilia in which IL-5 and IL-33 cytokines are crucial. “Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia.” Conor M Finlay, Kingston H.G. Mills, et al. (Dec 2016) J Immunol 196(2): 703-714.
Liver Fluke secretions suppress Experimental Autoimmune Encephalitis in mice Read More »
A nice review by the master. “B10 cells: a functionally defined regulatory B cell subset” T F Tedder (2015) J Immunol 194(4): 1395-1401. PMID: 25663677 Related Ancell Antibody Products anti-human CD24 anti-human CD27 anti-human CD19
B regulatory cells! Read More »
Despite the pronounced proliferative effect of recombinant pentameric GITRL on T cells, MC38 adenocarcinoma tumor failed to regress due to suppressive effect of accumulating Treg in tumor tissue and draining lymph node. “Authentic GITR Signaling Fails to Induce Tumor Regression unless Foxp3+ Regulatory T Ccells Are Depleted” Y.H. Kim, B.S. Kwon, et al. (2015) J
GITR signaling induces proliferation of both Teff and Treg cells in mice Read More »
This Danish research group used a cocktail of Ancell Biotinylated anti tetraspan antibodies, anti-CD9, anti-CD63 and anti-CD81 to detect microvesicles captured on EV microarray. The ability to characterize plasma derived exosomes in a high throughput manner may be very helpful in diagnosing cancer prognosis. “Potentials and capabilities of the Extracellular Vesicle (EV) Array” Malene Mǿller
Extracellular Vesicles Phenotyped with Microarray and Ancell mAbs Read More »
Internalized ApoD is colocalized in intracellular vesicular compartments with CD147. Downregulation of CD147 results in lower ApoD internalization. Induction of CD147 overexpression resulted in increased ApoD internalization. CD147 is a putative receptor for ApoD. “Apolipoprotein D Internalization Is a Basigin-dependent Mechanism” Ouafa Najyb, Louise Brissette, Eric Rassart (June 2015) J Biol Chem 290: 16077-16087. PMID:
CD147(Basigin) Facilitates Apolipoprotein D Cellular Internalization Read More »
This group demonstrated that physiologic levels of HDL act as an effective opsonin, facilitating uptake of M41-type Group A Streptococcus by human monocyte cell line U-937. Pre incubation with anti-CD36 antibody (clone SM0) completely blocked this phagocytosis. “High-density lipoprotein acts as an opsonin to enhance phagocytosis of group A streptococcus by U937 cells.” Ling Liu,
High Density Lipoprotein augments CD36 mediated phagocytosis of Group A Streptococcus Read More »
“CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28−CD8+ T Cells” J Leitner, P Steinberger, et al. (2015) J Immunol 195(2): 477-87. PMID: 26041540. Related Ancell Research Products anti-CD2 mAb (clone 1E7E8 UMCD2) anti-CD58(LFA-3) (clone TS2/9)
“Polyfunctional, Pathogenic CD161+ Th17 Lineage Cells Are Resistant to Regulatory T Cell–Mediated Suppression in the Context of Autoimmunity” S A Basdeo, J M Fletcher, et al. (2015) J Immunol 195(2): 528-540. PMID 26062995. Ancell anti-Human CD161 antibody Products
Matched pair of anti-human CD155(PVR) mAbs for Flow Cytometry and EIA Clone ANC2B2 Purified 255-020 Biotinylated 255-030 Clone ANC6A3 Purified 350-020 Biotinylated 350-030 Recombinant Soluble Poliovirus Receptor CD155-muIg Binds to Ligand(s) Upregulated on Stimulated Human Peripheral Blood Lymphoid Cells Recombinant Human CD155(PVR)-muIg Purified CD155-muIg 555-020 Biotinylated
New CD155(PVR) Products Available! Read More »
