CD36 is a scavenger receptor which can bind to various ligands as well as long chain fatty acids. It plays a role in innate immunity as well as metabolism. The authors use transport inhibitors, and uptake of 14-C labeled Phosphate diester of alpha-Tocopheryl (Vitamin E ) to implicate the CD36/PI3Ky as an important pathway for […]
CD36/PI3Ky pathway identified for VEGF expression by monocytes Read More »
Visit Ancell at the 2016 Autumn Immunology Conference Nov 18 – 20 at the downtown Marriott in Chicago!
Ancell at AIC 2016 Read More »
Ancell anti-human FOXP3 mAb and Biotin conjugate now available! Other conjugates coming soon! Clone ANCFX2D7 Purified mAb 333-020 Biotinylated 333-030 FITC 333-040 PE 333-050
New FOXP3 mAb Now Available! Read More »
“Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells” Xuehui He, Ruben L Smeets, Esther van Rijssen, Annemieke MH Boots, Irma Joosten, Hans JPM Koenen. (2016) Dissertation Submitted for Publication, Radbound Univ Med Center and Groningen Univ Med Center, The Netherlands. Ancell anti-CD28 Superagonist Clone ANC28.1/5D10
Ancell anti-CD28 superagonist mAb used to expand Treg cells Read More »
Adding Low density lipoprotein to FITC labeled Group A Steptococcus increased U-937 phagocytosis rate. This effect was blocked when cells were pre incubated with Ancell anti-CD36 mAb clone SMO. “LDL acts as an opsonin enhancing the phagocytosis of group A Streptococcus by monocyte and whole human blood” Lulei Zhou, Runlin Han, et al. (2016) Medical
Anti-CD36 mAb blocks phagocytosis of Steptococcus/LDL mixture Read More »
Come and visit Ancell at the American Association of Immunologist’s meeting in Seattle May 13 – May 16th, booth #816. Ask for an Ancell T shirt. They go fast!
Ancell at AAI 2016 Seattle! Read More »
Macrophages derived in culture from SLE patients are directed into secreting proinflammatory cytokines by anti-C1q auto antibodies bound to immobilized C1q complement protein. Pre blocking these monocytes with anti-CD32 (FcgRII ) F(ab’)2 reduced cytokine secretion levels significantly. “Anti-C1q Autoantibodies from Systemic Lupus Erythematosus Patients Induce a Proinflammatory Phenotype in Macrophages.” Sophia Thanei, Marten Trendelenburg J
Using TALEN(Transcription Activator-Like Effector Nucleases) technology, these researchers from Seattle Children’s Research succeeded in restoring copies of CD154( CD40L) gene with 3’ UTR under control of its endogenous promoter in human T cells from a patient with X-Linked Hyper-IgM Syndrome (X-HIGM). “Targeted gene editing restores regulated CD40L expression and function in X-HIGM T cells.” N
Neutrophil Extracellular Trap (NET) is a mechanism by which bacteria and other pathogenic organisms are rendered trapped in a site of inflammation. An activated Neutrophil extrudes it own genomic DNA, rich with histones and other proteins, to trap invading pathogenic organisms. However, in SLE patients, a distinct subset of Neutrophils, Low Density Granulocytes (LDGs) are
“Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1” S Jutz, P Steinberger, et al. (2016) J Immunol Methods pii: S0022-1759(16)30007-2. PMID: 26780292 Relevant Ancell Products anti-human TCR Cb1 mAb anti-human CD3e mAb CD272(BTLA) CD279(PD-1) CD137(4-1BB) anti-human CD28 (superagonist) mAb
Engineered T cell reporter line may further elucidate T cell signal pathway intricacies Read More »
