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CD30 and CD134 receptors are necessary for CD4 dependent autoimmune tissue damage

Abrogation of CD30 and OX40 signals prevents autoimmune disease in FoxP3-deficient mice.  Gaspal F.M., P.J.L Lane, et al. (2011) JEM 208(8): 1579-1584.   Ancell Products anti-human CD30 antibody products anti-human CD134(OX40) antibody products anti-human CD252(OX40L) antibody products Recombinant human CD134(OX40) Recombinant human CD252(OX40L)

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CD28 Superagonist protects against Rheumatoid Arthritis mediated bone destruction

In mice, use of CD28 superagonist has been shown to increase the % of Treg cells, and protect from Rheumatoid Arthritis mediated bone destruction.Marlo M Zaiss, Jean-Pierre David, et al. (2010) J Immunol 184: 7238-7246. Ancell anti-CD28 antibody clone ANC28.1/5D10 has been characterized as a superagonist. This mAb has been found to be capable of stimulating

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