ANC28.1 mAb used as a Control in a Modified Chandler-loop model developed to screen and assess drug toxicity

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ANC28.1 mAb used as a Control in a Modified Chandler-loop model developed to screen and assess drug toxicity

This system could potentially prevent disastrous clinical human trials like the TGN1412 (anti-CD28) one.  

“Extracorporeal human whole blood in motion as a tool to predict first-infusion reactions and mechanism-of-action of immunotherapeutics”  E A K Fletcher, S M Mangsbo, et al. (Jan 2018) International Immunopharmacology 54: 1-11.

 

Related Ancell Research Products

anti-human CD28 Superagonist mAb clone: ANC28.1

anti-human CD3 Agonist mAb clone UCHT1