A Lipopeptide Nasal Spray inhibits SARS-CO-V2 infection in Ferrets

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Nasal spray contains a cholesterol linked lipopeptide which binds to the S2 region of SARS-CO-V2 spike in proximity to the HR2 domain. This prevents it from contracting towards the HR1 domain and therby inhibits cell fusion and infection.

“Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets” Rory D. de Vries, Matteo Porotto, et al (Nov 2020) bioRxiv doi: 10.1101/2020.11.04.361154 PMID: 33173865